Undergrad: Université de Montréal - Archambault lab - Institute for Research in Cancer and Immunology
Grad school: University of North Carolina at Chapel Hill - Maddox lab - Biology department
As a graduate student in the Maddox lab at UNC Chapel Hill, I've been asking the fundamental question of how a nucleus comes to be a functional organelle within the cell. This is an essential process as every cell must form a new nucleus following cell division and condensed sperm chromatin must expand into a functional pronucleus following fertilization across organisms. We've been using mathematical modelling, several model organisms (mammalian cells, fly embryos, worm embryos, frog egg extracts) and quantitative live-cell microscopy approaches (tracking, morphological analyses, fluorescence intensity quantifications, etc) to determine the molecular requirements of nuclear expansion and assembly. Mostly though, being able to collaborate with several students, post-docs and labs from all walks of life on image analysis problems has been incredibly rewarding. Don't hesitate to reach out if you want to collaborate!
Once I get my degree (someday?), I'll be shifting my focus to work on algal symbiosis and metabolism to address how hosts regulate their algal symbionts, how this regulation affects algal metabolism and how algal endosymbionts in turn regulate their hosts. This work is inspired by our observations of the symbiotic relationship in the wild ciliate Stentor pyriformis under the supervision of Wallace Marshall (UCSF) in the context of the Physiology course hosted by the Marine Biological Laboratory in Woods Hole, MA.